CJC-1295 & Ipamorelin & GHRP-2 Blend (9mg)

Description

CJC 1295, Ipamorelin, and GHRP-2 are all synthetic peptides that appear to stimulate the release of growth hormones in the body. Studies suggest that all three peptides appear synergistic when combined as a blend, potentially providing unique peptide effects. 

CJC 1295 and Ipamorelin peptides fall under growth hormone secretagogues (GSHs). This implies that while these peptides may stimulate the release of growth hormones in the body, they are not growth hormone release peptides (GHRP). Similarly, GHRP-2 is a synthetic peptide analogous to the naturally occurring peptide called Ghrelin.⁽¹⁾ GHRP-2 peptides appear to trigger the release of growth hormones in the body and increase food intake and metabolism.⁽²⁾

Chemical Makeup ^(3,4,5)

Molecular formula:
CJC-1295: C₁₅₂H₂₅₂N₄₄O₄₂
Ipamorelin: C₃₈H₄₉N₉O₅
GHRP-2: C₄₅H₅₅N₉O₆

Molecular weight:
CJC 1295: 3367.9 g/mol
Ipamorelin: 711.9 g/mol
GHRP-2: 818.0 g/mol

Other known titles:
CJC 1295 peptide:

• CJC 1295 with DAC
• CJC 1295 without DAC

Both forms of the CJC 1295 peptide essentially exert the same effect; however, the addition of DAC (known as the drug affinity complex) appears to change the duration of the effect of the peptide. CJC 1295 with DAC may have a longer-lasting effect than CJC 1295 without DAC.

Ipamorelin:

• Ipamorelin Acetate
• IPA

GHRP-2:

• Pralmorelin
• Growth hormone-releasing peptide-2

Research 

CJC 1295, Ipamorelin, GHRP-2 blend, and Growth Hormone Secretagogues (GSHs)

In one clinical trial⁽⁶⁾, the safety and efficacy of growth hormone secretagogues and growth hormone-releasing peptides in human volunteers were studied. Several candidates were subjected to the GSHs, after which all the candidates were monitored for any physiological changes. As an outcome of this rigorous study, it was concluded that these peptides appeared to improve growth rates in children, increasing appetite and improving lean mass in adults. In obese candidates, these peptides were reported to stimulate a reduction in bone turnover, increase lean mass, and improve the sleep cycle. 

While the current studies indicate that these peptides are well tolerated, some concerns need further examination. As per this study, these peptides “increase lean body mass, [reduce] fat mass, [increase] exercise tolerance and maximum oxygen uptake, [enhance] muscle strength, and [improve] linear growth. Long-term studies of GH administration offer conflicting results”.⁽⁶⁾ While studies involving human participants such as this have been conducted, CJC 1295, Ipamorelin, GHRP-2 peptide blend is not intended for human consumption. 

CJC 1295, Ipamorelin, GHRP-2 blend and growth hormone deficient subjects

Numerous clinical studies have been conducted on individuals with growth hormone deficiency. These studies are recorded here for educational and research purposes; studies like these are ongoing and do not offer conclusive evidence of peptide efficacy. In these clinical trials, peptides stimulating growth hormone release demonstrated efficacy in two ways – either via stimulating the pituitary gland to release growth hormones or acting on the arcuate nucleus of the hypothalamus. While these peptides (including GHRP-2, Ipamorelin, and CJC 1295) appeared to demonstrate high releases of growth hormones, it remains unclear which of the two mechanisms worked in vivo. In addition, these studies suggested that these peptides may modulate food intake, cardiac tone, and sleep through specific receptor agonistic effects.⁽⁷⁾

In another study,⁽⁸⁾ six growth hormone-deficient children facing growth failure were subjected to growth hormone-stimulating peptides. All children were monitored for episodic growth hormone secretion and toxicity levels during this period. For the duration of the study and short while afterwards, It was observed that there was a gradual rise in the concentration of growth hormones in all children. As per V Mericq et al., the studies suggested that the peptides were “well tolerated and […] stimulate GH secretion.” Studies such as this one are still underway,  and these peptides require further research.

CJC 1295, Ipamorelin, GHRP-2 blend, and body hormones

The primary purpose of this study⁽⁹⁾ was to determine the effects of growth hormone-stimulating peptides on other bodily hormones, like adrenocorticotropic hormone (ACTH), prolactin, and cortisol concentration in men. The candidates were divided into groups, administered the peptides, and the results were compared. It was observed that the growth hormone levels in both groups appeared to increase significantly after peptide administration, with the concentration being much higher in the younger group compared to the elders.

CJC 1295, Ipamorelin, GHRP-2 blend, and food intake

In this study⁽¹⁰⁾, healthy males were administered with growth hormone release-stimulating peptides and then taken to buffet-style meals to measure food intake. It was noted that the candidates administered with the peptides ate approximately 36% more than the regular candidates did. In addition, the growth hormone levels also increased in these individuals, suggesting the effect the peptides had on both food intake and growth hormone levels. As per this study, the growth hormone release-stimulating peptides appeared to be a “valuable tool for investigating the effects on eating behavior in humans.” Research studies are still ongoing to fully explore the effects of peptide blends on humans. The peptide blend available in the market is for research and educational purposes, not human consumption.

 

References:

Garcia JM, Merriam GR, Kargi AY. Growth Hormone in Aging. [Updated 2019 Oct 7]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com https://www.ncbi.nlm.nih.gov/books/NBK279163/
Laferrère, Blandine et al. “Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men.” The Journal of clinical endocrinology and metabolism vol. 90,2 (2005): 611-4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824650/
National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 91976842, CJC1295 Without DAC. https://pubchem.ncbi.nlm.nih.gov/compound/CJC1295-Without-DAC.
National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 9831659, Ipamorelin. https://pubchem.ncbi.nlm.nih.gov/compound/Ipamorelin.
National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 6918245, Pralmorelin. https://pubchem.ncbi.nlm.nih.gov/compound/Pralmorelin.
Sigalos, John T, and Alexander W Pastuszak. “The Safety and Efficacy of Growth Hormone Secretagogues.” Sexual medicine reviews vol. 6,1 (2018): 45-53. doi:10.1016/j.sxmr.2017.02.004 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632578/
Rogério G. Gondo et al, Growth Hormone-Releasing Peptide-2 Stimulates GH Secretion in GH-Deficient Patients with Mutated GH-Releasing Hormone Receptor, The Journal of Clinical Endocrinology & Metabolism, Volume 86, Issue 7, 1 July 2001, Pages 3279–3283, https://doi.org/10.1210/jcem.86.7.7694.
Mericq V, Cassorla F, Salazar T, Avila A, Iñiguez G, Bowers CY, Merriam GR. Effects of eight months treatment with graded doses of a growth hormone (GH)-releasing peptide in GH-deficient children. J Clin Endocrinol Metab. 1998 Jul;83(7):2355-60. https://pubmed.ncbi.nlm.nih.gov/9661608/
Emanuela Arvat, Lidia Di Vito, Barbara Maccagno, Fabio Broglio, Muni F Boghen, Romano Deghenghi, Franco Camanni, Ezio Ghigo, Effects of GHRP-2 and Hexarelin, Two Synthetic GH-Releasing Peptides, on GH, Prolactin, ACTH and Cortisol Levels in Man. Comparison with the Effects of GHRH, TRH and hCRH, Peptides, Volume 18, Issue 6, 1997, Pages 885-891, ISSN 0196-9781, https://doi.org/10.1016/S0196-9781(97)00016-8
Laferrère, Blandine et al. “Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men.” The Journal of clinical endocrinology and metabolism vol. 90,2 (2005): 611-4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824650/

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NOTE: These products are intended for laboratory research use only. CJC-1295 Ipamorelin GHRP2 blend for sale is not intended for personal use. Please review and adhere to our Terms and Conditions before ordering.