Palmitoyl tetrapeptide-7 is a small peptide composed of four amino acids: palmitoyl, glycine, glutamine, and arginine.(1) It is a synthetic peptide analog of the natural matrikine peptide, which is considered to play a vital role in regulating extracellular matrix (ECM) turnover and cellular activities.
Initial research suggests Palmitoyl Tetrapeptide-7 peptide acts by stimulating the synthesis of ECM components, such as collagen and elastin, and inhibiting the production of pro-inflammatory cytokines. It may also modulate gene expression involved in ECM remodeling, cell proliferation, and inflammation.(2)
Moreover, Palmitoyl Tetrapeptide-7 may function by suppressing the activity of interleukin-6 (IL-6), a pro-inflammatory cytokine that plays a role in skin aging and inflammation. IL-6 secretion is considered to increase with age, leading to the degradation of the ECM, resulting in sagging and wrinkling of the skin.
Chemical Makeup (1)
Molecular Formula: C34H62N8O7
Molecular Weight: 694.9 g/mol
Other known titles
Research and Clinical Studies
Palmitoyl Tetrapeptide-7 Mechanism of Action
Based on animal studies, Palmitoyl Tetrapeptide-7 has been suggested to potentially inhibit the activity of matrix metalloproteinases (MMPs) in animal models.(3) MMPs are a group of enzymes that may degrade ECM proteins during normal tissue growth. By downregulating MMP activity, Palmitoyl Tetrapeptide-7 may prevent ECM damage and allow cells to restore and maintain the ECM.
This peptide’s mechanism of action is speculated to be similar to that of dehydroepiandrosterone, sometimes called the “youth hormone.”
Palmitoyl Tetrapeptide-7 and Oral Conditions
Given the inhibitory potential of the peptide on matrix metalloproteinases (MMPs), research findings suggest that Palmitoyl Tetrapeptide-7 may also potentially mitigate the symptoms of some oral conditions. MMPs enzymes may break down extracellular matrix (ECM) proteins, including those in the oral cavity. While these enzymes are considered to play a role in various physiological and pathological processes, including tissue repair, wound healing, and inflammation, excessive MMP activity might result in tissue damage and may cause various oral diseases, such as periodontitis, caries, and oral cancer. Studies have also suggested that MMP activity is upregulated in some oral conditions, including periodontitis, characterized by the destruction of periodontal tissues. The possible inhibition of MMP activity by Palmitoyl Tetrapeptide-7 might potentially prevent or slow the progression of periodontitis (and other oral ailments) by preserving the integrity of the ECM.(3)
Palmitoyl Tetrapeptide-7 and Skin Damage
Studies suggest that the peptide may stimulate the synthesis of collagen, a key component of the extracellular matrix in the skin, and may produce anti-inflammatory action, which might reduce damage caused by environmental factors such as UV radiation and pollution.
Research has suggested that combining Palmitoyl Tetrapeptide-7 with Palmitoyl Oligopeptide (Matrixyl 3000) may synergistically stimulate collagen production and reduce inflammation. This synergy, which the study describes as “dramatic,” may help improve skin texture and reduce the appearance of fine lines and wrinkles.(4)
As per the studies, “Matrixyl 3000 is a synergistic combination of two skin active peptides, Palmitoyl oligopeptide and Palmitoyl-tetrapeptide-7, which appears promising based on the preliminary data from the manufacturer (Sedema corporation). However, it remains to be proven effective by independent published clinical studies.”
Palmitoyl Tetrapeptide-7 and Anti-Aging
In a randomized, double-blind, placebo-controlled clinical study, 20 female test subjects with mild to moderate facial wrinkles were presented with a cream containing Palmitoyl Tetrapeptide-7 for 12 weeks. The cream was applied twice daily to the face and neck.
At the end of the study period, the researchers reported that the cream containing Palmitoyl Tetrapeptide-7 appeared to have improved the appearance of facial wrinkles compared to the placebo cream.(5) The researchers also observed an apparently significant increase in skin elasticity in the group that received the Palmitoyl Tetrapeptide-7 cream.
In another study, 20 test subjects were presented with the peptide compound twice a day for four weeks, and instrumental measurements were taken to assess the improvement of skin aging. The study reported an apparent reduction in fine wrinkles by 5.97% after two weeks and 14.07% after four weeks, and a reported increase in skin elasticity by 6.81% after two weeks, and 8.79% after four weeks. Dermal density was reportedly increased by 16.74% after two weeks, and 27.63% after four weeks.(6)
Palmitoyl Tetrapeptide-7 is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering.
- National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 10078408, Palmitoyl tetrapeptide-7. https://pubchem.ncbi.nlm.nih.gov/compound/Palmitoyl-tetrapeptide-7
- Mondon P, Hillion M, Peschard O, Andre N, Marchand T, Doridot E, Feuilloley MG, Pionneau C, Chardonnet S. Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications. J Cosmet Dermatol. 2015 Jun;14(2):152-60. doi: 10.1111/jocd.12135. Epub 2015 Mar 27. PMID: 25817264. https://pubmed.ncbi.nlm.nih.gov/25817264/
- Sorsa T, Tjäderhane L, Salo T. Matrix metalloproteinases (MMPs) in oral diseases. Oral Dis. 2004 Nov;10(6):311-8. doi: 10.1111/j.1601-0825.2004.01038.x. PMID: 15533204. https://pubmed.ncbi.nlm.nih.gov/15533204/
- Matrixyl 3000 (palmitoyl oligopeptide & palmitoyl tetrapeptide-7): Back to the future of skin care. Available at: http://www.smartskincare.com/treatments/topical/palmitoyl-oligopeptide-palmitoyl-tetrapeptide-7-matrixyl-3000.html
- Marta Salvador-Ferreira et al. Trending Anti-Aging Peptides. MDPI Journal, Vol 7, Issue 4. https://www.mdpi.com/2079-9284/7/4/91
- Hahn Hyung Jin et al. Instrumental evaluation of anti‑aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E and other functional ingredients on aged human skin, Experimental and Therapeutic Medicine, Jun 2016. https://www.researchgate.net/publication/303887266_Instrumental_evaluation_of_anti-aging_effects_of_cosmetic_formulations_containing_palmitoyl_peptides_Silybum_marianum_seed_oil_vitamin_E_and_other_functional_ingredients_on_aged_human_skin
NOTE: These products are intended for laboratory research use only. Palmitoyl Tetrapeptide-7 (topical) for sale (200mg) is not intended for personal use. Please review and adhere to our Terms and Conditions before ordering.
Dr. Marinov (MD, Ph.D.) is a researcher and chief assistant professor in Preventative Medicine & Public Health. Prior to his professorship, Dr. Marinov practiced preventative, evidence-based medicine with an emphasis on Nutrition and Dietetics. He is widely published in international peer-reviewed scientific journals and specializes in peptide therapy research.