Chonluten, also known as EDG tripeptide, contains a natural peptide complex that may restore normal physiological processes of the respiratory pathway by reinforcing the synthesis of proteins. It may potentially restore mechanisms of anabolism and catabolism, which are pivotal to organism health. Chonluten is a peptide complex containing glycine, glutamine, and asparagine, which is considered to normalize the performance of bronchial mucous membrane cells.(1)
Primarily, Chonluten has been researched for its potential to normalize the impact on target organs by replacing or supporting the activity of substances secreted by these morphological structures through immunomodulation. It may increase the lifespan of mesenchymal stem cells (MCS) and possibly induce molecular mechanisms that contrast senescence.
Chonluten appears to be organ-specific, with its primary potential exhibited in lung tissues, possibly extending action in the gastrointestinal tract.(2) Chonluten may revitalize, regulate, and otherwise possibly provide premium refurbishment to the airway and bronchial mucosa.
Molecular Formula: C11H17N308
Molecular Weight: 319.27
PubChem CID: 194641
Synonyms: Glu-asp-gly, Glutamyl-aspartyl-glycine, H-Glu-asp-gly-OH, T-34 tripeptie
Cas No: 75007-24-8
IUPAC Condensed: 4S)-4-amino-5-[[(2S)-3-carboxy-1-(carboxymethyl amino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Hydrogen Bond (donor count): 6
Hydrogen Bond (acceptor count): 9
Rotatable Bond: 10
Topological Polar Surface: 196 Å²
Heavy Atom Count: 22
Exact Mass: 319.10156451
Research and Clinical Studies
Chonluten Peptide and Lungs and GI Tract
As the lung capacity reduces with age, researchers suggest Chonluten may decrease the rate of cell death while encouraging proliferative activity via protection of the bronchial lining. (2) The bronchial inner lining is a barrier between the external environment and internal structures. Different inflammatory diseases can affect this inner lining, and may change mucus production and extracellular matrix structure. Chonluten’s proposed mechanisms of action may to alleviate inflammatory conditions within the lungs.
Chonluten’s suggested impact on the GI tract is reportedly similar to that in the lungs, with studies positing its potential to reduce inflammation and prevent the prevalence of vascular changes that induce inflammatory diseases.
Chonluten Peptide and Gene Expression
Short peptides, such as Chonluten, have been researched in the context of certain modes of DNA expression, such as DNA methylation.(4, 5) Research suggests that:
‘Short peptides, consisting of 2-7 amino acid residues, can penetrate into the nuclei and nucleoli of cells and interact with the nucleosome, the histone proteins, and both single- and double-stranded DNA. DNA-peptide interactions, including sequence recognition in gene promoters, are important for template-directed synthetic reactions, replication, transcription, and reparation. Peptides can regulate the status of DNA methylation, which is an epigenetic mechanism for the activation or repression of genes in both the normal condition, as well as in cases of pathology and senescence’.(4)
Chonluten Peptide and the Immune System
Research studies suggest Chonluten may regulate the immune system, stimulating or suppressing it to respond to advancing conditions. Chonluten’s possible mechanisms of action have been suggested to be mediated by many genes, including heat shock protein, gene HSP70, SOD, c-Fos, antioxidative system genes, and TNF-alpha. The regulation of such genes may result in anti-inflammatory impacts, particularly c-Fos—considered a protein bioregulator of cell differentiation, survival, and proliferation that is activated in response to hypoxia and cellular damage. Although c-Fos may induce the growth of new blood vessels and cell proliferation at the local level in response to an injury, progressive expression might result in thickened bronchial mucosa or cancer.(2)
Chonluten Peptide and Anaerobic Activity
Research studies have grappled with the role of Chonluten peptide in various clinical anaerobic studies: ‘Studies have confirmed that several bioactive peptides elicit strongly upregulating effects on muscle protein synthesis or increase muscular strength and recovery. This is of special interest for sports, where large forces against an object or opponent (e.g., combat sports) are needed. Interestingly, recent discussions in the scientific community address the fact that these peptides may also be helpful for reducing injuries and accelerating return-to-sport. Besides positive effects on strength and recovery, recent investigations found that hydrolyzed proteins might also influence endurance performance and metabolism.’(6)
Chonluten peptide is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering.
- Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A, Mironova E, Pulcini R, Robuffo I, Bologna G, Simeone P, Lanuti P, Guarnieri S, Trofimova S, Procopio AD, Toniato E. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. Int J Mol Sci. 2022 Mar 25;23(7):3607
- V. K. Khavinson, N. S. Lin’kova, A. V. Dudkov, V. O. Polyakova, and I. M. Kvetnoi, “Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins,” Bull. Exp. Biol. Med., vol. 152, no. 5, pp. 615–618, Mar. 2012, DOI: 10.1007/s10517-012-1590-2
- Khavinson VK, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021 Nov 22;26(22):7053
- Khavinson VK, Lin’kova NS, Tarnovskaya SI. Short Peptides Regulate Gene Expression. Bull Exp Biol Med. 2016 Dec;162(2):288-292
- König D, Kohl J, Jerger S, Centner C. Potential Relevance of Bioactive Peptides in Sports Nutrition. Nutrients. 2021 Nov 10;13(11):3997. DOI: 10.3390/nu13113997
- V. Khavinson, N. Linkova, A. Dyatlova, B. Kuznik, and R. Umnov, “Peptides: Prospects for Use in the Treatment of COVID-19,” Molecules, vol. 25, no. 19, p. 4389, Sep. 2020, DOI: 10.3390/molecules25194389
NOTE: These products are intended for laboratory research use only. Chonluten for sale (20mg) is not intended for personal use. Please review and adhere to our Terms and Conditions before ordering.
Dr. Marinov (MD, Ph.D.) is a researcher and chief assistant professor in Preventative Medicine & Public Health. Prior to his professorship, Dr. Marinov practiced preventative, evidence-based medicine with an emphasis on Nutrition and Dietetics. He is widely published in international peer-reviewed scientific journals and specializes in peptide therapy research.