Studies of Hexarelin in Cell Health

Hexarelin peptide, also known as examorelin, is a deeply researched, synthetic GHRP that is gaining the attention of scientists and researchers.

This article will provide some answers regarding hexarelin benefits, hexarelin side effects, and other details about this peptide.

What Is Hexarelin?

Hexarelin’s a new synthetic GHRP with the ability to provide cardioprotective results. This peptide could be utilized in a lab setting to explore the roles of ghrelin, which requires acylation to bind to GHS-R1a and consists of twenty eight (28) amino acids.

Hexarelin gets part of its name from hexapeptide since the peptide is made of 6 amino acids. The other part of its name comes from the fact that it’s a synthetic analog of ghrelin. Thus, the name came to be hexa(six) and (gh)relin, hexarelin.

Autophagy management is considered a contributor to cardioprotection. One study investigated the function of potential governing mechanisms and autophagy, and found that heart muscle cells’ hypertrophy, cell death, and oxidative stress were all inhibited by hexarelin treatment.

Hexarelin peptide also managed the upward autophagy signalling by slowing the mTOR phosphorylation. Researchers of this study proposed that hexarelin acts the new function of reducing hypertrophy of heart muscle cells and cell death.

Hexarelin is used primarily to stimulate the pituitary gland, thus causing a production of growth hormones. Similar to its growth hormone releasing peptide counterparts, it acts by inhibiting somatostatin functions, while elevating GH levels by magnifying the GHRH signal transduction pathway.

Hexarelin Peptide Structure, Weight

Hexarelin has a molecular structure of C47H58N12O6 and a molecular weight of 887 grams per mole. Its sequence is His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2, and it has a chemical abstract service (CAS) registry of 140703-51-1 [ref 1].

What Does Hexarelin Do?

Hexarelin functions using particular receptors at both the hypothalamic and pituitary levels to promote GH discharge in non-human test subjects. There is a notion that the release of growth hormone using PKC signaling is affected by Hexarelin. It copies the ghrelin function by attaching to GHS-R1a. It also attaches to and fires up the cardiac receptors.

Hexarelin possesses significant adrenocorticotropin and prolactin cortisol-releasing activity, similar to other growth hormone releasing peptides. Thyroid-stimulating hormone, luteinizing hormone, IGF-1, follicle-stimulating hormone, and plasma glucose are unaffected by the administration of hexarelin.

Difference Between Hexarelin and Other GHRPs

Upon data examination, it’s apparent that Hexarelin contains unique aspects that other GHRPs do not. Actually, among the GH releasers, Hexarelin turns out to be the most potent.

On a microgram to microgram level comparison, hexarelin exceeds the other GH releasing peptides in performance. Though it hasn’t been proven, evidence exists that shows an increased, accelerated desensitization rate as opposed to other research peptides, but the rate and extent of this are still being studied regardless.

What Is Used For?

Hexarelin has presented the potential use for joint restoration, protection, and healing, neural protection, muscle fiber size increase, and enhanced strength when administered on non-human lab subjects.

The peptide is also thought to decrease overall fatty tissue, which helps the subjects lose fat. Any form of growth, however, is solely a result of the rise in hormone levels; gastric draining isn’t accelerated, and appetite is not stimulated.

How Is Used in Research?

Researchers have been suggested to stop Hexarelin use within 2 weeks of initial administration on test subjects. Doing otherwise may lead to an insignificant rise in GH because of the increased desensitization.

However, a study that opposes that idea was conducted. The experiment was performed on non-human test subjects to find out Hexarelin’s desensitization rate in daily administration.

The subjects’ blood was drawn four (4) times over sixteen (16) weeks and analyzed. Upon evaluation, the researchers concluded that Hexarelin presented an insignificant difference in desensitization after the first and fourth week of administration.

The dosages used in the study included a daily administration of 1 and 2mg/kg, and the level of released GH was dampened after sixteen (16) weeks.

Peptide Results on Non-Human Subjects

Non-human subjects that were administered Hexarelin presented with muscle size increases resulting from new myocytogenesis. A number of subjects even started looking more youthful in their appearance.

Hexarelin also displayed accelerated injury recovery and, in some cases, was observed to have benefited the heart. Non-human subjects without the ability to generate their own HGH naturally, were administered.

The peptide is also recognized for its ability to enhance skin elasticity. Altogether, Hexarelin aids in:

• injury prevention and recovery
• reduction of fat
• muscle building
• skin elasticity

Hexarelin Benefits

Hexarelin has been shown to provide a variety of benefits, but its most prominent potential advantages are involved with fat regulation, cardiac or heart protection, and muscle mass preservation.

Can Hexarelin Regulate Fat?

Evidence exists that supports hexarelin’s role as a CD36 agonist, which is a protein that has to do with lipolysis control, and management of fatty acid breakdown. Treating the cultured murine adipose with hexarelin resulted in CD36 activation, which then drew out the reduced expression of PEPCK [ref 2].

Since PEPCK is linked to the breakdown of fatty acids, this implies that this process is regulated by CD36, and is thus activated by this peptide. Abnormal amounts of fat in the blood are referred to as dyslipidemia. Its impact on human physiology is crucial to fighting the rising health concerns linked to modern diets.

Rodent research demonstrates that growth hormone-releasing peptide 6 (GHRP-6) can fix dyslipidemia in an insulin resistance setting (1st step to diabetes) while lowering blood sugar and insulin resistance at the same time.

Hexarelin could potentially provide an alternative to the lipid medications we currently use to treat severe dyslipidemia.

Can Hexarelin Protect the Heart?

Some studies have found that Hexraelin is linked to positive effects on these tissues, especially in instances of disease or injury. Evidence also exists indicating hexarelin’s potential ability to relieve lesion formation in rodent atherosclerosis models.

Hexarelin affects the heart directly by attaching to the CD36 receptor and the GHSR. Rodent studies state that the peptide guards heart cells against injury heart attack settings by attaching to these receptors and inhibiting cells from going through programmed cell death (aka apoptosis).

Also, examorelin treated rodents presented a higher number of surviving heart cells, reduced formation of malondialdehyde (an indicator of heart cell death), and better cardiac function.

Another study found that hexarelin decreases oxidative stress in cardiac failure and inhibits remodeling of heart muscles from occurring. Remodeling is a process having to do with a decrease in cardiac function and morbidity [ref 3].

GHRP 6 treated rodents in this study showed major enhancements in heart function. The processes are considered to be arbitrated by GHRP 6 down regulation of protein kinase B expression and up-regulation of PTEN activity.

Since the mechanism that Hexarelin uses to protect cardiac cells is not particular to the damage mechanism in myocardial infarctions, scientists thought that hexarelin may be utilized to protect the heart from further injuries.

Once again, a study on rodents found that the peptide enhanced cardiac function in a diabetes model by manipulating the way potassium and calcium are processed by myocardial cells.

Can Hexarelin Protect Muscle Mass?

Hexarelin might provoke a rise in calcium influx by activating the GHS-R1a, as mentioned before, it might not have this impact on skeletal muscle. Also, Hexarelin has displayed the ability to improve isolated skeletal muscle contractility of rats in a way that is significantly calcium-independent and dose-dependent.

Hexarelin doesn’t just protect the heart muscles. Rodent studies of cachexia models have shown that GHRP 6 protects myocytes by managing calcium flow and mitochondrial dysfunction. Mitochondria are the power plants of cells.

Without them, cells can’t generate the energy necessary to perform normal function and will die eventually. Calcium dysregulation is a major reason why lean body mass and muscle mass are impacted during cancer treatment.

Side Effects

Commonly observed side effects with hexarelin may be due to its impact on prolactin, cortisol, and ACTH. These adverse effects include:

• Low libido
• Tingling or numbness in extremities
• Lethargy
• Elevated cortisol levels
• Water retention
• Carpal tunnel-like symptoms
• Elevated prolactin levels
• Excessive sleepiness
• Reduced insulin sensitivity

Where to Buy Hexarelin Peptide?

You can buy Hexarelin and other high quality peptides for research only by visiting Core Peptides.

 

References:

1. National Center for Biotechnology Information. PubChem Database. Examorelin CID 6918297. 2020.
2. Ma Y, et al. Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium. PLoS One Journal, 2012.
3. Wan Z, et al. FAT/CD36 regulates PEPCK expression in adipose tissue. American journal of physiology. Cell physiology, 2013.

 

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