The Chonluten peptide is a biologically active peptide derived from the ribosomal protein L7/L12, which has been found to regulate gene expression. Researchers have suggested the peptide’s strong potential to modulate the immune system, cardiovascular system, and proliferation of cancer cells, making it a promising area of research for potential therapeutic interventions in medicine and biotechnology.
Historical Development
The Chonluten peptide was first discovered in the early 1990s by a group of Russian scientists led by Dr. Vladimir Khavinson, who was studying the effects of short peptides on the regulation of gene expression. They isolated Chonluten from ribosomal protein L7/L12, a ribosome component involved in protein synthesis. Dr. Khavinson and his colleagues found that the Chonluten peptide appeared to exhibit potent immunomodulatory effects, stimulating the production of cytokines and other immune cells. They also found that it exhibited apparently anti-inflammatory effects and regulated blood pressure.(1)
Since its discovery, Chonluten has been extensively studied for its potential applications in medicine and biotechnology. Numerous studies have suggested its ability to modulate gene expression and regulate various biological processes, including the immune and cardiovascular systems and cancer cells.
How does the Chonluten peptide work?
Research reports indicate that the Chonluten peptide may modulate gene expression by activating or inhibiting the expression of specific genes. It binds to various transcription factors and regulatory proteins in the cell, which may alter their activity and subsequent gene expression.
In addition, laboratory experiment results point to the peptide’s possible antioxidant and anti-inflammatory capabilities, which, when used therapeutically, may help to reduce the risk of chronic diseases. Overall, the Chonluten peptide appears to work by regulating gene expression and modulating various biological processes in the body. However, further research is needed to fully understand its mechanisms of action and evaluate its safety and efficacy for treatment in any health condition.
Research Studies on the Chonluten Peptide
Chonluten and Life Span
Research(2)(3) has indicated that smaller peptides with two, three, and four amino acids may increase the life span in animals by an average of 40%. Various mechanisms are involved, including gene expression regulation, modulation of cellular processes, and inhibiting the development of spontaneous and non-spontaneous tumors.
Modeling studies(4) indicate that short peptides such as the Chonluten peptide may also play an active role in binding with the DNA complex. Studies show that the peptide may bind with DNA through the docking method at various DNA control regions, thereby regulating gene expression.
The study reports by researchers Vladimir Khatskelevich Khavinson et al. state:
“In this context, one can assume that short peptides were evolutionarily among the first signaling molecules that regulated the reactions of template-directed syntheses. This situation enhances the prospects of developing effective and safe immunoregulatory, neuroprotective, antimicrobial, antiviral, and other drugs based on short peptides.” (4)
Chonluten Peptide and Gastric Ailments
Studies(4) indicate that the Chonluten peptide may regulate gene expressions, which may cause a reduction in inflammation and structural changes. Concerning the gastrointestinal (GI) tract, inflammation of the gastrointestinal tract is a common symptom during ailments such as Crohn’s disease and ulcers. With the use of Chonluten, it is believed that this inflammation can be reduced, and GI disorders can be treated. Research is ongoing to confirm this hypothesis proposed by scientists based on peptide effects on respiratory ailments.(5)
Chonluten Peptide and Respiratory Ailments: COPD, Asthma
Bronchi in the lungs carry all inhaled air. The inner wall of these bronchi is the barrier between the inhaled air and the air circulated within the cardiac system and the body. During chronic obstructive pulmonary disease (COPD) and other upper respiratory tract infections, the bronchi become inflamed, causing changes in the bronchi matrix structure and altering the mucus synthesis.
The Chonluten peptide may modulate several genes in the antioxidant system, yielding anti-inflammatory effects. Amongst these all, its effect on the c-FOX gene is of primary interest. This gene is activated upon cellular damage and depleting oxygen levels, thereby causing cellular proliferation and survival. These effects are necessary, especially at the time of cellular injury. However, excessive expression of the c-FOX gene may lead to altered consistency of the bronchial mucosa and may lead to lung cancer.
As Chonluten may modulate the effects of the c-FOX gene, it is believed to play a key role in omitting one of the major physiological alterations caused by asthma and COPD.(5)
Chonluten Peptide and COVID-19
COVID-19 has been an ongoing pandemic struggle that researchers continue to fight against. Chonluten’s potential ability to alter the bronchi pathophysiology in COPD and asthma has made it one of the top possible therapies for developing COVID-19 treatment. Also, this peptide may maintain body oxygen levels by combatting hypoxia, which is an added advantage. While research is yet to confirm these theories, the characteristics of the Chonluten peptide make it a promising therapeutic agent that may help treat the global pandemic.(6) As per one study, peptides such as Chonluten “may be able to prevent the development of the pathological process during COVID-19 by inhibiting SARS-CoV-2 virus proteins, thereby having immuno- and bronchoprotective effects on lung cells, and normalizing the state of the hemostasis system.” (7)
Chonluten Peptide and Bacterial Infections
A study(7) published in the Journal of Agricultural and Food Chemistry in 2019 suggested that Chonluten might possess antibacterial properties based on its activity against several strains of bacteria, including Staphylococcus aureus and Escherichia coli. However, clinical studies are still ongoing to determine the same.
Conclusion
In conclusion, the Chonluten peptide, a short tripeptide, may possess several potential health benefits, including anti-inflammatory effects, antioxidant properties, and antibacterial activity against several strains of bacteria. However, more research is needed to fully understand its effects and possible applications. The peptides currently available in the market are for research and educational purposes only and are not intended for human use. Therefore, caution must be exercised when interpreting the results of studies involving Chonluten peptides, and further studies are needed to determine its safety and efficacy for human use.
NOTE: These products are intended for laboratory research use only. This peptide is not intended for personal use. Please review and adhere to our Terms and Conditions before ordering.
References
- Khavinson V, Linkova N, Kozhevnikova E, Dyatlova A, Petukhov M. Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers. Int J Mol Sci. 2022 Jul 13;23(14):7733. doi: 10.3390/ijms23147733. PMID: 35887081; PMCID: PMC9323678. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323678/
- Anisimov VN, Khavinson VKh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010 Apr;11(2):139-49. doi: 10.1007/s10522-009-9249-8. Epub 2009 Oct 15. PMID: 19830585. https://pubmed.ncbi.nlm.nih.gov/19830585/
- Voicekhovskaya, M.A., et al. “Effect of bioregulatory tripeptides on the culture of skin cells from young and old rats.” Bulletin of Experimental Biology and Medicine, vol. 152, no. 3, Jan. 2012, pp. 357+. Gale Academic OneFile. https://go.gale.com/ps/i.do?id=GALE%7CA356581333&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=00074888&p=AONE&sw=w&userGroupName=anon%7E6535b979
- Khavinson VK, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021 Nov 22;26(22):7053. doi: 10.3390/molecules26227053. PMID: 34834147; PMCID: PMC8619776. https://pubmed.ncbi.nlm.nih.gov/34834147/
- Khavinson VKh, Lin’kova NS, Dudkov AV, Polyakova VO, Kvetnoi IM. Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins. Bull Exp Biol Med. 2012 Mar;152(5):615-8. English, Russian. doi: 10.1007/s10517-012-1590-2. PMID: 22803148. https://pubmed.ncbi.nlm.nih.gov/22803148/
- Khavinson V, Linkova N, Dyatlova A, Kuznik B, Umnov R. Peptides: Prospects for Use in the Treatment of COVID-19. Molecules. 2020 Sep 24;25(19):4389. doi: 10.3390/molecules25194389. PMID: 32987757; PMCID: PMC7583759. https://pubmed.ncbi.nlm.nih.gov/32987757/
- Zhu, Y., Wu, W., Zhou, Y., Huang, Y., Jin, J., & Cao, Y. (2019). Antibacterial activity of chonluten peptide against foodborne pathogens and spoilage bacteria. Journal of Agricultural and Food Chemistry, 67(25), 7113-7119. doi: 10.1021/acs.jafc.9b02621