Epitalon peptide – also commonly referred to as Epithalamin and Epithalon – is another rigorously researched peptide among many others. Scientists aim to discover more about its potential properties and if it can positively contribute to therapeutic treatment developments. Despite promising discoveries, researchers are still investigating this peptide to isolate its mechanism of action and safety profile.

It is a synthetic tetrapeptide, that it is made up of 4 amino acids – Glutamic, Glycine, Aspartic, and Alanine acids. It has a molecular structure of C14H22N4O9, and a molecular weight of about 390.35 grams per mole. It has a sequence of H-Ala-Glu-Asp-Gly-OH, and its CAS (Chemistry Abstracts Service) registry number is 64082-79-7. Epitalon peptide is the same as the natural Epithalamin peptide, a hormone created by the pineal gland.

Epitalon (aka Epithalon) is involved in metabolic functions, raising the hypothalamus’s sensitivity to its natural hormone affects the regulation of melatonin levels in non-human test subjects’ bodies, correcting the circadian rhythm. During research assessments, Epitalon has presented enhanced results with regards to aspects of anti-aging, and prolonging life expectancy. Researchers report a positive impact regarding inhibiting colon, prostate, and breast cancer cell conception and reproduction. Prof. Vladimir Khavinson, a Russian scientist, discovered Epitalon and studied it rigorously for over thirty-five years. His findings suggested Epitalon’s ability to improve sleep, prevent cancer, and reverse aging.

Epitalon Composition

Epitalon is typically handled in its lyophilized powder state. The powder is dilutable, using a mild solution of acetic acid or water, preferably distilled. The peptide is fairly stable for about three months in its powder state and at room temperature. However, it requires a storage temperature of four degrees celsius (4ºC) once it is diluted.

Epitalon can then be used for research, safely, for about 2 to 21 days, so long as it stays stored at that temperature. If the researcher wishes to extend the life of the solution, they would have to store it at minus 18 degrees celsius (-18ºC).

Epitalon Research

Since experimenting with Epitalon, researchers have reported several potential properties exhibited through peptide administration in test subjects.  Scientists are aware that telomeres are responsible, in part, for the aging of the organs and cells. Among the many effects resulting from cell exposure to Epitalon is an apparent elongation of telomere, thus at the cellular level, potentially inhibiting, halting, and sometimes even reversing aging effects. Studies report that cell regeneration and healing have been apparent after the cells’ exposure to the peptide.

When carefully observed through a microscope, non-human animal cells have presented that correction to some degree takes place at the level of the subject’s DNA, presenting potential hypotheses for results regarding the repair and regeneration of cells. Researchers have suggested Epitalon’s potential to govern the subject’s melatonin and cortisol levels, as well as a potential to regulate issues within the reproductive systems of female rodents. This regulation has been informing researchers about how cells manage themselves, further educating them on how each system functions. When tumors were exposed to Epitalon, various types of tumors reportedly became smaller, and some of the damage caused throughout their growth was even reversed.

Epitalon Peptide and Anti-Aging Research

Researchers have reported that the test subjects exposed to Epitalon appear to be living longer than their nonexposed counterparts. Some subjects’ mortality rates have even been reduced by as much as fifty percent, prolonging their lifespan by nearly 1.5 times longer than subjects exposed to mere placebos. The epitalon-exposed rodents with prolonged lifespans were also prevented from acquiring Leukemia (any form); this was not true for the control group, the subjects of which received only the placebo.

Epitalon may promote telomerase formation; it is a natural enzyme that aids in the cells’ reproduction of telomeres. Telomeres are protective elements of DNA, and they prevent the loss of genetic information. The function of telomeres results in the shortening of chromosomes, which takes place during cell division. Any time cells divide, telomeres shrink, which is why this process is closely associated with age-related diseases, such as cognitive or cardiovascular diseases, and inevitably, death.

With the intentional activation of telomerase, cells may potentially acquire the ability to continue multiplying, and even surpass their expiration date. By doing so, the mechanism of aging may be reversed since longer telomere strands result in improved cell health and reproduction. Epitalon, therefore, may play a function in slowing the aging process and reducing its effects, and can potentially prolong lifespan.

Any form of impact that Epitalon may exhibit requires the measurement of an endpoint – health span, aging biomarkers, or life span. Aging biomarkers must meet the following criteria:

  • Supervise the underlying process of aging
  • Needs to be effective on non-human, lab animals
  • Endure repeated assessment with the test subject remaining unharmed
  • Besides chronological age, it should also forecast lifespan

Prof. Vladimir Khavinson, in the course of over 30 years, conducted experiments on rodents and suggested telomere elongation results from their activation – both of which may potentially be caused by Epitalon exposure. Studies have displayed researchers’ ability to manipulate a gene to reverse age-related deterioration in rodents – albeit partially. Prior to moving deeper into details, it’s crucial to get a better grasp on the aging process.

Depending on and determined by their DNA, cells play particular roles in the bodies within which they reside. As cells age, they release toxins around them, and they have a limited life time. The older (senior) cells then go through the process of programmed cell death (or apoptosis) in efforts to protect the organism. Unfortunately, rather than dying off, these old cells can sometimes stimulate diseases in tissues of other organs (liver, brains, kidney, heart, etc.), without ever being detected.

There is reasonable suspicion among researchers that aging may be due to these old cells and their devious behavior. An experiment was performed on genetically engineered rodents that were manipulated to age far before their natural time, setting them at an age equivalent to an eighty year old human that is ready to die of age. The rodents’ telomeres were short and dysfunctional, and experienced a variety of age-related problems (shrunken brain, damaged intestines, impaired sense of smell, atrophied spleens, etc.).

The hypothesis of the researchers was that, by promoting the telomerase activity – an enzyme that makes small DNA units called telomeres (which shut tight the chromosome tips, thus keeping the genes within from coming undone) – early aging could potentially be treated. The rodents were administered Epitalon by the researchers. After just one month, the rodents appeared to exhibit signs of revitalization. Their telomerase levels were higher, and their telomeres had grown longer, altogether. As a result, the animals’ organs showed better function overall. The treated rodents grew their spleen, got back their olfactory sense, and the dormant stem cells of their brains grew in size and even formed new neurons.

At the end of the experiment, the rodents treated with Epitalon displayed the physiological equivalence of human youth and thus a prolonged lifespan. Clinical trials of the peptide have suggested similar advantageous impacts reflected by the betterment of various organs’ conditions.

The potential anti-aging and life prolonging properties of Epitalon peptide are exhibited through action on telomerase, the enzyme that telomeres in the body longer and guards DNA from age-related damage. Upon their multiplication, cells have a given amount of cycles they can perform. According to studies conducted by Prof Khavinson, cells exposed to Epitalon produced a total of 44 passages, 10 additional divisions as opposed to regular cells.

Aging and Melatonin

Melatonin levels are kept up and managed by the pineal gland. Investigations displayed a notable reduction in melatonin concentration in the blood of aging, non-human animals.

The hormone Melatonin plays a crucial role in nervous, endocrine, and immune system functioning. Bringing in melatonin forms a geroprotective impact. This impact, though, could aggravate possible adverse effects (i.e. neoplastic growth). This brought about the need to look for a way to adequately stimulate the secretion of natural, internal melatonin.

Epitalon has been suggested by researchers to function as an antioxidant and reduced the age-related effects in both the neuroendocrine and immune systems, thus the occurrences of infections and diseases were reportedly decreased.

Epitalon and Cancer Research

Epitalon may slow the expansion of malignant tumors and, by activating melatonin secretion, inhibits the advancement of metastasis. By examining the connection between the cancer and pineal gland, we can see how this happens. The pineal gland appears to be stimulated by Epitalon to secrete melatonin (a hormone). Research presents a converse relationship between cancerous tumor growth (in various organs) and melatonin.

Epitalon and Sleep Research

Melatonin produced from the stimulated pineal gland (by epitalon) is responsible for patterns of deep sleep. Potentially, the more the pineal gland is exposed and stimulated by Epitalon, the more melatonin is released, enhancing sleep.

Epitalon and Longevity, Antioxitant and Vision Research

Researchers suggest Epitalon may stimulate the generation of telomerase, thus elongating and strengthening telomeres in the DNA strands. This reduces apoptosis and prolongs lifespan, which in turn may inhibit age-related diseases.

Regarding removing free radicals, the peptide has been suggested by research studies to provide potential antioxidant properties. It may remove oxygen-free radicals contributing to cell destruction – the primary cause of degenerative diseases like Alzheimer’s.

In rodents with hereditary Retinitis Pigmentosa, Epitalon was reported by researchers to exhibit workable integrity of their eyes’ retina. For patients with pigmentary retinal degeneration, it appeared to enhance their overall vision.

Epitalon Safety Profile

Little is known about the potential adverse effects of Epitalon, and more research has to be done to establish a safety profile. The studies mentioned in this article have found no apparent, significant side effects. There has been a single report of a test subject experiencing a brief moment within which the muscles of the eyes (used to focus) were a little strained.

Researchers can buy Epitalon and other high-quality peptides for research by visiting CorePeptides.com/peptides. The peptide is strictly available for research and not approved for human use.

buy Epitalon peptide

Epitalon peptide (25mg) vial – Core Peptides




  1. Anisimov VN, Khavinson VKh, Alimova IN, et al. Epithalon decelerates aging and suppresses the development of breast adenocarcinomas in transgenic her-2/neu mice. Bull Exp Biol Med, 2002.
  2. Kossoy G, Anisimov VN, Ben-Hur H, et al. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo, 2006.
  3. Alimova IN, Bashurin DA, Popovich IG, et al. Effect of Epitalon and Vilon treatment on mammary carcinogenesis in transgenic erbB-2/NEU mice. Vopr Onkol, 2002.
  4. Khavinson VKh. Peptides and Ageing. Neuro Endocrinol Lett, 2002.
  5. Kozina LS, Arutjunyan AV, Khavinson VKh. Antioxidant properties of geroprotective peptides of the pineal gland. Arch Gerontol Geriatr, 2007.
  6. Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med, 2003.



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