BPC 157 (Body Protectant Compound 157) is a stable, synthetic gastric peptide that contains fifteen amino acids (aka a pentadecapeptide). BPC is short for Body Protection Compound – also frequently called Bepecin and PL10. The peptide is a BPC portion that is separated from human gastric juice. It is dissimilar to natural gastric peptides, and is synthetic. However, it may have more stability than other peptides, and may endure the breakdown of gastric acid for a minimum of 24 hours.

BPC is one of the body’s natural elements and has displayed the potential to boost healing in non-human animals during experiments. Aside from its intestinal repair activity, BPC appears to generate similar results in various other tissues. Experiments using non-human subjects found that the potential healing mechanisms of BPC-157 are, to a degree, linked to the human growth hormone.

BPC-157 Peptide Research

Various studies on animal subjects suggested that BPC-157 stimulates healing in injuries such as transected muscle and IBD [1]. Another study conducted using rodents posited that a portion of the healing response may be due to increased growth hormone receptor expression in the damaged tissues exposed to BPC peptides [2].

Normal tissue healing involves a great number of growth factors to take place. Just a few of these growth factors include transforming GF beta, growth hormone, IGF, and platelet-derived GF. Both the particular damaged tissue and the extent of its damage determine the function that is taken on by each growth factor. Growth hormone is highly active in connective tissue repair – tissues such as cartilage, bone, muscle, tendons, and ligaments. BPC-157 has exhibited potential to boost collagen secretion, and collagen is a protein that functions as the foundation for a number of other connective tissues. By promoting GH recruitment to injured tissue, BPC-157 may speed up the recovery process.

BPC-157 Peptide and Fibroblast Activity

Fibroblasts are roaming cells present in the majority of connective tissues (bones, tendons, muscle, gastric mucosa, skin, etc.). When tissue is injured, fibroblasts rush to the damaged area to start the repair process. They may also split and multiply in an effort to have more fibroblasts available if necessary.

Research has suggested that concentrations of BPC peptide may impact fibroblast relocation; higher BPC levels have been found to indicate more fibroblast relocation. Studies in the past have suggested that BPC manages the roles of collagen fragments by stimulating fibroblast function, which are responsible for the maintenance and deposition of collagen. Research has also hypothesized that BPC-157 has an impact on fibroblasts through its expression up-regulation of the GH receptor gene. This basically means that Body Protection Compound 157 may have the potential to manipulate DNA function.

Finally, besides being an attractant, certain research has supported the theory that Body Protection Compound 157 may significantly accelerate migration of fibroblasts, as opposed to natural bodily functions without the peptide. In addition to their reactive migration, another major response is fibroblast reproduction (or outgrowth) in response to BPC-157, which researchers reported appeared to be about 3x higher when exposed to Body Protection Compound [1].

Research shows BPC-157 may contain major healing properties in many different tissues such as bones, skeletal muscles, ligaments, and tendons. Current studies conducted on animal subjects propose that BPC-157 might impact numerous growth factors that are normally a part of blood vessel production (angiogenesis), as well as other factors involved in post-injury regeneration. While prior studies on animal subjects have suggested that both BPC altogether and BPC, in particular, stimulate healing, recent animal studies are beginning to gain insight into exactly how they are able to do that. In a nutshell, the BPC-157 peptide may be a promoter and modifier of the body’s natural healing system.

BPC-157 and Tendon Healing

Unfortunately, the casual recovery of neither ligaments or tendons is great, due to finite supply of blood in the body. After cutting rodents’ Achilles tendon transversely, BPC was reported to enhance healing, and soon after, the complete integrity of the tendon was restored [3]. Similar effects were observed when exploring ligament injuries in rodents. BPC displayed an enhancement in healing 3 months after the surgical cut. More research is needed in this area to understand the peptide’s mechanism of action and full impact.

BPC-157 and Brain Healing

BPC-157 has also been suggested to have a positive impact on edema, hemorrhages, and inflammation following traumatic brain damage and a number of serious brain pathologies resulting from liver/gastrointestinal lesions, or NSAID and insulin overdose. More research is needed in this area to understand the peptide’s mechanism of action and full impact.

BPC-157 and Blood Vessel Damage

BPC-157 exhibited a strong impact in some research studies for new blood vessel formation (angiogenesis), while also guarding the endothelium, and both inhibiting and reversing the formation of blood clots following an anastomosis of the abdominal aorta. BPC functions using various vasoactive routes may result in the betterment of the recovery process. Scientists are also exploring BPC-157’s role in:

  • Skin damage repair
  • Muscle injury repair
  • Bone healing
  • Sciatic nerve healing

BPC-157 Safety Profile

The significant majority of available studies haven’t found any side effects, but it is important to note all experiments use murine models and the peptide has not been studied in a clinical setting on human subjects. The most common BPC side effects found in research studies are those involved with the digestive system, and were typically reported to be intermittent and mild:

  • Diarrhea
  • Nausea
  • Bowel movement changes
  • Gas
  • Bloating

Additional side effects were reported:

  • Fatigue
  • Fluctuations in weight and appetite
  • Headache
  • Dizziness
  • Hot/Cold flashes

Researchers can find BPC-157 for sale online, but it’s best to use a trusted source. You can buy BPC 157 peptide for research by visiting Core Peptides. Note that the peptide is only available for educational and research purposes and is strictly unapproved for human consumption or personal use.

References:

  1. T. Cerovecki, I. B., et al. Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat, Orthopaedic Research Society, Pub. Wiley Periodicals, 2010.
  2. C.H. Chang, et al. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts, Mol. Basel Switzerland, 2014.
  3. Gwyer, D., et al. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Journal contribution, 2019.

 


 

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