Sermorelin peptide (also sometimes known as GRF 1-29) is an analogue of the growth hormone releasing hormone. It is the shortest chain of functional amino acids, with 29 linked acids, making it a very common substance for growth research, and allowing researchers to investigate the occurrence of growth in varying exposures.
More specifically, this polypeptide is the acetate salt of an amidated synthetic compound, corresponding to the amino terminal section of the GHRH. Because this peptide is so easily synthesized, a great amount of potential academic knowledge and understanding can come from studying Sermorelin, including potential uses for this substance in the future.
Sermorelin Research
Although study results have presented positive presentations from Sermorelin peptide administration, there is still plenty to learn about this fascinating substance. Researchers suggest the peptide may induce an increase the natural levels of growth hormone in test subjects via the stimulation of the pituitary glands. Sermorelin has been reported to exhibit initiated growth in test subjects – even after their time for natural growth has ended.
Both individual cells and subjects exposed to this peptide in lab settings have presented apparent significant levels of growth. The most effective results were presented when researchers administered the substance daily. Though more studies need to be done, post-exposure toxicity from Sermorelin within the subjects has not been evident. Regarding its duration, the half-life of Sermorelin peptide is quite short-lived – just about 12 minutes or so – but the subjects appear to feel its effects very quickly.
How Does Sermorelin Work?
By exciting the pituitary gland, Sermorelin may be able to increase the body’s natural growth hormone levels in the test subjects. This is done through a process wherein the peptide itself binds to the GHRH receptor and imitates the local growth hormone-releasing factor (GRF), as GRF has been reported to promote growth hormone secretion in subjects. To explain in more depth, the elevated concentration of human growth hormone (HGH) secreted by the pituitary gland has been reported in initial research findings to an increase in the liver’s formation of Insulin-Like Growth Factor 1, producing the advantageous effects to the subject under study. Since the pituitary gland’s secretion and body’s concentration of human growth hormone is already increased, the subject’s endocrine system will not permit the further production of growth hormone than can be safely processed by the body, due to the endocrine self-monitoring system.
Because of the way Sermorelin appears to present in the body, the blood stream’s elevated levels of IGF-1 may lead to new cell growth within the bones and organs of the subjects’ body, as well as an increase in their metabolism. Researchers have reported that Sermorelin may be more beneficial for application in age management and treatment – as opposed to the recombinant human growth hormone (rhGH). This is because Sermorelin does not appear to lead to the excessive elevation of circulating human growth hormone, and to greatly contain somatotroph function by means of decline from disuse, it does not promote or speed up the aging effects.
Researchers have studied Sermorelin peptide for it’s potential to induce the following effects:
- Potential to increase in lean muscle mass
- Potential to reduce body fat
- Potential to increase bone density
- Potential to enhance the immune system
- Potential to enhance heart strength
- Potential to increase the strength of various other organs in the body
- Potential to increase cognitive performance
- Potential to improve body composition
- Potential to increase hair and nail growth
- Potential to increase sleep quality
- Potential to reduce the risk for diseases such as heart disease, diabetes, stroke, and more
- Potential to enhance skin tone
- Potential to improve the overall quality of life
Researchers report that the start and development of Sermorelin-induced effects do not appear to be as fast as those of rhGH. There are additional steps in the process when the peptide is administered and used to produce these effects.
Sermorelin Safety Profile
Scientists reported side effects in some test subjects include swelling, redness, or pain at the adminstration site. Some of the less occurring side effects include the following:
- Trouble swallowing
- Itching
- Flushing
- Dizziness
- Headache
- Trouble sitting still
- Drowsiness
Laboratories and research facilities can buy Sermorelin and other high quality peptides for research at Core Peptides. The peptide has not been approved for use outside of a laboratory setting.
Sermorelin peptide (5mg) vial – Core Peptides
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Dr. Marinov (MD, Ph.D.) is a researcher and chief assistant professor in Preventative Medicine & Public Health. Prior to his professorship, Dr. Marinov practiced preventative, evidence-based medicine with an emphasis on Nutrition and Dietetics. He is widely published in international peer-reviewed scientific journals and specializes in peptide therapy research.